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Leutero 50 mg Injection is used to prevent harmful effects of methotrexate. It is also used to treat overdose of methotrexate.

Salt NameLeucovorin
ManufacturerHetero Drugs Ltd
Order Quantity Discount
1 - 5 10 %
5 - 10 12 %
10 - 15 14 %


LEUTERO (Calcium Folinate) – a natural metabolite of tetrahydrofolic acid, chemically, is a reduced formula of folic acid. LEUTERO, as an enzyme, also participates in the biosynthesis of nucleic acids (DNA, RNA), as well as folic acid. But for its metabolism dehydrofolate reductase is no longer used. LEUTERO is used as an antidote for drugs (cytostatics) that deactivate dehydrofolate reductase and folic acid, causing cell death. Moreover, LEUTERO has a selectivity of action in relation to healthy cells (a different mechanism of transport through the cytoplasmic membrane) and therefore, it is well combined with cytostatics in the treatment of tumors. In addition, LEUTERO being, in fact, an active metabolite of folic acid, completely replaces its participation in all metabolic processes (synthesis of heme and others).

In humans, LEUTERO is intensely involved in metabolic processes, metabolizing to tetrahydrofolic acid derivatives. The main active metabolite is 5 methyltetrahydrofolate, in the form of which all folates accumulate and are transported in the body. Intravenous administration of LEUTERO leads to a therapeutic effect for 5 minutes. The maximum concentration of the drug in the blood, when administered intramuscularly, is observed after 8-12 minutes, and the clinical effect requires about 15 minutes The main folate depot is the liver, where they accumulate about 50% and the main metabolism occurs.